Ontology highlight
ABSTRACT:
SUBMITTER: Combe M
PROVIDER: S-EPMC4617633 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Combe Marine M Garijo Raquel R Geller Ron R Cuevas José M JM Sanjuán Rafael R
Cell host & microbe 20151001 4
Genetic diversity enables a virus to colonize novel hosts, evade immunity, and evolve drug resistance. However, viral diversity is typically assessed at the population level. Given the existence of cell-to-cell variation, it is critical to understand viral genetic structure at the single-cell level. By combining single-cell isolation with ultra-deep sequencing, we characterized the genetic structure and diversity of a RNA virus shortly after single-cell bottlenecks. Full-length sequences from 88 ...[more]