Ontology highlight
ABSTRACT:
SUBMITTER: Welsh IC
PROVIDER: S-EPMC4617833 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Welsh Ian C IC Kwak Hojoong H Chen Frances L FL Werner Melissa M Shopland Lindsay S LS Danko Charles G CG Lis John T JT Zhang Min M Martin James F JF Kurpios Natasza A NA
Cell reports 20150924 2
Expression of Pitx2 on the left side of the embryo patterns left-right (LR) organs including the dorsal mesentery (DM), whose asymmetric cell behavior directs gut looping. Despite the importance of organ laterality, chromatin-level regulation of Pitx2 remains undefined. Here, we show that genes immediately neighboring Pitx2 in chicken and mouse, including a long noncoding RNA (Pitx2 locus-asymmetric regulated RNA or Playrr), are expressed on the right side and repressed by Pitx2. CRISPR/Cas9 gen ...[more]