Ontology highlight
ABSTRACT:
SUBMITTER: Araujo DJ
PROVIDER: S-EPMC4617974 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Araujo Daniel J DJ Anderson Ashley G AG Berto Stefano S Runnels Wesley W Harper Matthew M Ammanuel Simon S Rieger Michael A MA Huang Hung-Chung HC Rajkovich Kacey K Loerwald Kristofer W KW Dekker Joseph D JD Tucker Haley O HO Dougherty Joseph D JD Gibson Jay R JR Konopka Genevieve G
Genes & development 20151001 20
Mutations in the transcription factor Forkhead box p1 (FOXP1) are causative for neurodevelopmental disorders such as autism. However, the function of FOXP1 within the brain remains largely uncharacterized. Here, we identify the gene expression program regulated by FoxP1 in both human neural cells and patient-relevant heterozygous Foxp1 mouse brains. We demonstrate a role for FoxP1 in the transcriptional regulation of autism-related pathways as well as genes involved in neuronal activity. We show ...[more]