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Runx3 specifies lineage commitment of innate lymphoid cells.

ABSTRACT: Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses to external pathogens. While ILCs can be phenotypically classified into ILC1, ILC2 and ILC3 subsets, the transcriptional control of commitment to each ILC lineage is incompletely understood. Here we report that the transcription factor Runx3 was essential for the normal development of ILC1 and ILC3 cells but not of ILC2 cells. Runx3 controlled the survival of ILC1 cells but not of ILC3 cells. Runx3 was required for expression of the transcription factor ROR?t and its downstream target, the transcription factor AHR, in ILC3 cells. The absence of Runx3 in ILCs exacerbated infection with Citrobacter rodentium. Therefore, our data establish Runx3 as a key transcription factor in the lineage-specific differentiation of ILC1 and ILC3 cells.

SUBMITTER: Ebihara T

PROVIDER: S-EPMC4618046 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Runx3 specifies lineage commitment of innate lymphoid cells.

Ebihara Takashi T Song Christina C Ryu Stacy H SH Plougastel-Douglas Beatrice B Yang Liping L Levanon Ditsa D Groner Yoram Y Bern Michael D MD Stappenbeck Thaddeus S TS Colonna Marco M Egawa Takeshi T Yokoyama Wayne M WM

Nature immunology 20150928 11

Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses to external pathogens. While ILCs can be phenotypically classified into ILC1, ILC2 and ILC3 subsets, the transcriptional control of commitment to each ILC lineage is incompletely understood. Here we report that the transcription factor Runx3 was essential for the normal development of ILC1 and ILC3 cells but not of ILC2 cells. Runx3 controlled the survival of ILC1 cells but not of ILC3 cells. Runx3 was req ...[more]

PMID: 26414766

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