Ontology highlight
ABSTRACT:
SUBMITTER: Young LM
PROVIDER: S-EPMC4618055 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Young Lauren M LM Marzio Antonio A Perez-Duran Pablo P Reid Dylan A DA Meredith Daniel N DN Roberti Domenico D Star Ayelet A Rothenberg Eli E Ueberheide Beatrix B Pagano Michele M
Cell reports 20151008 3
PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replication fork protein TIMELESS, distinct from the known TIMELESS-TIPIN complex, which activates the intra-S phase checkpoint. TIMELESS recruitment to laser-induced sites of DNA damage is dependent on its b ...[more]