Ontology highlight
ABSTRACT:
SUBMITTER: Ray JP
PROVIDER: S-EPMC4618086 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Immunity 20150922 4
The differentiation of CD4(+) helper T cell subsets with diverse effector functions is accompanied by changes in metabolism required to meet their bioenergetic demands. We find that follicular B helper T (Tfh) cells exhibited less proliferation, glycolysis, and mitochondrial respiration, accompanied by reduced mTOR kinase activity compared to T helper 1 (Th1) cells in response to acute viral infection. IL-2-mediated activation of the Akt kinase and mTORc1 signaling was both necessary and suffici ...[more]