Suppressors of superoxide production from mitochondrial complex III.
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ABSTRACT:
SUBMITTER: Orr AL
PROVIDER: S-EPMC4618194 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
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Suppressors of superoxide production from mitochondrial complex III.
Orr Adam L AL Vargas Leonardo L Turk Carolina N CN Baaten Janine E JE Matzen Jason T JT Dardov Victoria J VJ Attle Stephen J SJ Li Jing J Quackenbush Douglas C DC Goncalves Renata L S RL Perevoshchikova Irina V IV Petrassi H Michael HM Meeusen Shelly L SL Ainscow Edward K EK Brand Martin D MD
Nature chemical biology 20150914 11
Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling inc ...[more]
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