Fast-folding proteins under stress.
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ABSTRACT:
SUBMITTER: Dave K
PROVIDER: S-EPMC4618258 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Fast-folding proteins under stress.
Dave Kapil K Gruebele Martin M
Cellular and molecular life sciences : CMLS 20150801 22
Proteins are subject to a variety of stresses in biological organisms, including pressure and temperature, which are the easiest stresses to simulate by molecular dynamics. We discuss the effect of pressure and thermal stress on very-fast-folding model proteins, whose in vitro folding can be fully simulated on computers and compared with experiments. We then discuss experiments that can be used to subject proteins to low- and high-temperature unfolding, as well as low- and high-pressure unfoldin ...[more]
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