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Symptomatic infection and detection of vaccine and vaccine-reassortant rotavirus strains in 5 children: a case series.


ABSTRACT: Vaccine or vaccine-reassortant rotavirus strains were detected in fecal specimens from 5 of 106 (4.7%) immunocompetent children who required treatment for rotavirus gastroenteritis at a large pediatric hospital in Texas in 2009-2010. Four strains were related to pentavalent rotavirus vaccine, whereas one was related to monovalent rotavirus vaccine. The contribution of these strains to each patient's illness was unclear given that 2 patients had prominent respiratory symptoms and 2 were concurrently infected with another pathogen (group F adenovirus and norovirus). Continued monitoring is necessary to assess the role of vaccine strains and vaccine-reassortant strains in pediatric rotavirus infections.

SUBMITTER: Boom JA 

PROVIDER: S-EPMC4618559 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Symptomatic infection and detection of vaccine and vaccine-reassortant rotavirus strains in 5 children: a case series.

Boom Julie A JA   Sahni Leila C LC   Payne Daniel C DC   Gautam Rashi R   Lyde Freda F   Mijatovic-Rustempasic Slavica S   Bowen Michael D MD   Tate Jacqueline E JE   Rench Marcia A MA   Gentsch Jon R JR   Parashar Umesh D UD   Baker Carol J CJ  

The Journal of infectious diseases 20120807 8


Vaccine or vaccine-reassortant rotavirus strains were detected in fecal specimens from 5 of 106 (4.7%) immunocompetent children who required treatment for rotavirus gastroenteritis at a large pediatric hospital in Texas in 2009-2010. Four strains were related to pentavalent rotavirus vaccine, whereas one was related to monovalent rotavirus vaccine. The contribution of these strains to each patient's illness was unclear given that 2 patients had prominent respiratory symptoms and 2 were concurren  ...[more]

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