Ontology highlight
ABSTRACT:
SUBMITTER: Ge XQ
PROVIDER: S-EPMC4618655 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Stem cell reports 20150716 2
Maintaining genomic integrity during DNA replication is essential for stem cells. DNA replication origins are licensed by the MCM2-7 complexes, with most of them remaining dormant. Dormant origins (DOs) rescue replication fork stalling in S phase and ensure genome integrity. However, it is not known whether DOs exist and play important roles in any stem cell type. Here, we show that embryonic stem cells (ESCs) contain more DOs than tissue stem/progenitor cells such as neural stem/progenitor cell ...[more]