Ontology highlight
ABSTRACT:
SUBMITTER: Xiao B
PROVIDER: S-EPMC4618760 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Xiao Bo B Han Moon Kwon MK Viennois Emilie E Wang Lixin L Zhang Mingzhen M Si Xiaoying X Merlin Didier D
Nanoscale 20151012 42
Nanoparticle (NP)-based combination chemotherapy has been proposed as an effective strategy for achieving synergistic effects and targeted drug delivery for colon cancer therapy. Here, we fabricated a series of hyaluronic acid (HA)-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs (HA-CPT/CUR-NPs) with various weight ratios of CPT to CUR (1 : 1, 2 : 1 and 4 : 1). The resultant spherical HA-CPT/CUR-NPs had a desirable particle size (around 289 nm), relative narrow size distrib ...[more]