Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69.
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ABSTRACT:
SUBMITTER: Singh G
PROVIDER: S-EPMC4619159 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69.
Singh Gurdeep G Zhou Xiaohong X Lee Jeong Yoon JY Yousuf Mohammad A MA Ramke Mirja M Ismail Ashrafali M AM Lee Ji Sun JS Robinson Christopher M CM Seto Donald D Dyer David W DW Jones Morris S MS Rajaiya Jaya J Chodosh James J
Virology 20150907
Viruses within human adenovirus species D (HAdV-D) infect epithelia at essentially every mucosal site. Hypervariable loops 1 and 2 of the hexon capsid protein contain epitopes that together form the epsilon determinant for serum neutralization. We report our analyses comparing HAdV-D15, 29, 56, and the recently identified type 69, each with highly similar hexons and the same serum neutralization profile, but otherwise disparate genomes. Of these, only HAdV-D type 56 is associated with epidemic k ...[more]
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