Ontology highlight
ABSTRACT:
SUBMITTER: Cho S
PROVIDER: S-EPMC4619203 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cho Sungpil S Park Hongsuk H Jarboe Elke A EA Peterson C Matthew CM Bae You Han YH Janát-Amsbury Margit M MM
PloS one 20151021 10
Cancer stem cells (CSCs) are a small subset of cancer cells responsible for maintenance and progression of several types of cancer. Isolation, propagation, and the differentiation of CSCs in the proper stem niches expose the intrinsic difficulties for further studies. Here we show that induced cancer like stem cells (iCLSCs) can be generated by in vitro oncogenic manipulation of mouse embryonic stem cells (mESCs) with well-defined oncogenic elements; SV40 LTg and HrasV12 by using a mouse stem vi ...[more]