Unknown

Dataset Information

0

Common Polymorphisms in the NFKBIA Gene and Cancer Susceptibility: A Meta-Analysis.


ABSTRACT: NFKBIA encodes the inhibitors of nuclear factor-?B (NF-?B), which regulate the translation of the genes involved in the inflammatory and immune reactions. Polymorphisms (rs2233406, rs3138053, and rs696) of NFKBIA have been implicated in susceptibility to many cancer types.To evaluate the association between polymorphisms of NFKBIA and cancer susceptibility, a meta-analysis including a total of 7182 cancer cases and 10 057 controls from 28 case-control studies was performed. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.Combined data demonstrated that rs3138053 polymorphism of NFKBIA was associated with cancer susceptibility in an allelic model (C vs. T: OR=10.754, 95%CI=4.175-27.697, Pheterogeneity=0.000), while the polymorphism of rs696 appeared to play a protective role in tumorigenesis (CC+CT vs. TT: OR=0.879, 95%CI=0.787-0.982, Pheterogeneity=0.107). When stratification analysis was performed by cancer type, an increased association of rs3138053 was recognized in hepatocarcinoma (C vs. T: OR=42.180, 95%CI=27.970-63.612, Pheterogeneity=0.007), while a decreased association of rs696 was identified in Hodgkin lymphoma (C vs. T: OR=0.792, 95%CI=0.656-0.956, Pheterogeneity=0.116; CC vs. TT: OR=0.658, 95%CI=0.448-0.965, Pheterogeneity=0.076; CC vs. CT+TT: OR=0.734, 95%CI=0.562-0.958, Pheterogeneity=0.347). By ethnicity, rs696 appears to be a protective candidate among Caucasians (CT vs. TT: OR=0.809, 95%CI=0.676-0.969, Pheterogeneity=0.459).Our data demonstrated that the rs3138053 polymorphism of NFKBIA gene is a candidate for susceptibility to overall cancers, while rs696 plays a protective role.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC4621165 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Common Polymorphisms in the NFKBIA Gene and Cancer Susceptibility: A Meta-Analysis.

Zhang Meng M   Huang Junjie J   Tan Xiuxiu X   Bai Jian J   Wang Hao H   Ge Yukun Y   Xiong Hu H   Shi Jizhou J   Lu Wei W   Lv Zhaojie Z   Liang Chaozhao C  

Medical science monitor : international medical journal of experimental and clinical research 20151021


<h4>Background</h4>NFKBIA encodes the inhibitors of nuclear factor-κB (NF-κB), which regulate the translation of the genes involved in the inflammatory and immune reactions. Polymorphisms (rs2233406, rs3138053, and rs696) of NFKBIA have been implicated in susceptibility to many cancer types.<h4>Material and methods</h4>To evaluate the association between polymorphisms of NFKBIA and cancer susceptibility, a meta-analysis including a total of 7182 cancer cases and 10 057 controls from 28 case-cont  ...[more]

Similar Datasets

| S-EPMC6757245 | biostudies-literature
| S-EPMC3573054 | biostudies-other
| S-EPMC5342795 | biostudies-literature
| S-EPMC4483960 | biostudies-literature
| S-EPMC6909495 | biostudies-literature
| S-EPMC8490044 | biostudies-literature
| S-EPMC4713578 | biostudies-other
| S-EPMC5561993 | biostudies-literature
| S-EPMC7138992 | biostudies-literature
| S-EPMC4846049 | biostudies-literature