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CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration.

ABSTRACT: Three high-density lipoprotein (HDL)-related loci have been reported to be associated with age-related macular degeneration (AMD), but the results were inconsistent. In this study, the cholesteryl ester transfer protein (CETP) rs3764261 variant was significantly associated with an increased risk of AMD (odds ratio [OR]?=?1.13, 95% confidence interval [CI]: 1.05-1.21, P?

SUBMITTER: Wang YF 

PROVIDER: S-EPMC4621603 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration.

Wang Ya-Feng YF   Han Yue Y   Zhang Rui R   Qin Li L   Wang Ming-Xu MX   Ma Le L  

Scientific reports 20151027

Three high-density lipoprotein (HDL)-related loci have been reported to be associated with age-related macular degeneration (AMD), but the results were inconsistent. In this study, the cholesteryl ester transfer protein (CETP) rs3764261 variant was significantly associated with an increased risk of AMD (odds ratio [OR] = 1.13, 95% confidence interval [CI]: 1.05-1.21, P < 0.001), and the hepatic lipase (LIPC) rs10468017 variant was associated with a significantly decreased risk of AMD (OR = 0.81,  ...[more]

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