Ontology highlight
ABSTRACT:
SUBMITTER: Mandriota SJ
PROVIDER: S-EPMC4621910 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Mandriota Stefano J SJ Valentijn Linda J LJ Lesne Laurence L Betts David R DR Marino Denis D Boudal-Khoshbeen Mary M London Wendy B WB Rougemont Anne-Laure AL Attiyeh Edward F EF Maris John M JM Hogarty Michael D MD Koster Jan J Molenaar Jan J JJ Versteeg Rogier R Ansari Marc M Gumy-Pause Fabienne F
Oncotarget 20150701 21
Neuroblastoma, a childhood cancer with highly heterogeneous biology and clinical behavior, is characterized by genomic aberrations including amplification of MYCN. Hemizygous deletion of chromosome 11q is a well-established, independent marker of poor prognosis. While 11q22-q23 is the most frequently deleted region, the neuroblastoma tumor suppressor in this region remains to be identified. Chromosome bands 11q22-q23 contain ATM, a cell cycle checkpoint kinase and tumor suppressor playing a pivo ...[more]