Ontology highlight
ABSTRACT:
SUBMITTER: Seagle BL
PROVIDER: S-EPMC4621916 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Seagle Brandon-Luke L BL Eng Kevin H KH Dandapani Monica M Yeh Judy Y JY Odunsi Kunle K Shahabi Shohreh S
Oncotarget 20150701 21
The objective of this study was to determine if ovarian cancer patients with a TP53 mutation grouped by location of the mutation within the p53 protein structure exhibit differential survival outcomes. Data from patients with high grade serous ovarian cancer (HGS OvCa) (N = 316) or breast cancer (BrCa) (N = 981) sequenced by The Cancer Genome Atlas (TCGA) was studied by Kaplan-Meier and Cox proportional hazards survival analysis. A TP53 DNA binding domain (BD) missense mutation (MM) occurred in ...[more]