Ontology highlight
ABSTRACT:
SUBMITTER: Sudha G
PROVIDER: S-EPMC4622218 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Sudha Govindarajan G Singh Prashant P Swapna Lakshmipuram S LS Srinivasan Narayanaswamy N
Protein science : a publication of the Protein Society 20150908 11
Residue types at the interface of protein-protein complexes (PPCs) are known to be reasonably well conserved. However, we show, using a dataset of known 3-D structures of homologous transient PPCs, that the 3-D location of interfacial residues and their interaction patterns are only moderately and poorly conserved, respectively. Another surprising observation is that a residue at the interface that is conserved is not necessarily in the interface in the homolog. Such differences in homologous co ...[more]