Ontology highlight
ABSTRACT:
SUBMITTER: Huang YM
PROVIDER: S-EPMC4622220 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20150908 11
Signaling in cells often involves co-localization of the signaling molecules. Most experimental evidence has shown that intracellular compartmentalization restricts the range of action of the second messenger, 3'-5'-cyclic adenosine monophosphate (cAMP), which is degraded by phosphodiesterases (PDEs). The objective of this study is to understand the details of molecular encounter that may play a role in efficient operation of the cAMP signaling apparatus. The results from electrostatic potential ...[more]