Ontology highlight
ABSTRACT:
SUBMITTER: Azzopardi N
PROVIDER: S-EPMC4622710 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Azzopardi Nicolas N Dupuis-Girod Sophie S Ternant David D Fargeton Anne-Emmanuelle AE Ginon Isabelle I Faure Frédéric F Decullier Evelyne E Roux Adeline A Carette Marie-France MF Gilbert-Dussardier Brigitte B Hatron Pierre-Yves PY Lacombe Pascal P Leguy-Seguin Vanessa V Rivière Sophie S Corre Romain R Bailly Sabine S Paintaud Gilles G
mAbs 20150101 3
Hereditary hemorrhagic telangiectasia (HHT), a genetic vascular disorder associated with epistaxis and hepatic shunts, is responsible for high-output cardiac failure in rare cases. Bevacizumab, which targets vascular endothelial growth factor, was shown to decrease both cardiac index (CI) and epistaxis duration in HHT patients with severe liver involvement. The relationship between its serum concentration and change in both CI and epistaxis duration was investigated to design the bevacizumab mai ...[more]