Ontology highlight
ABSTRACT:
SUBMITTER: Ying T
PROVIDER: S-EPMC4622838 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ying Tianlei T Wang Yanping Y Feng Yang Y Prabakaran Ponraj P Gong Rui R Wang Lili L Crowder Karalyne K Dimitrov Dimiter S DS
mAbs 20150101 5
Engineered antibody domains (eAds) are promising candidate therapeutics but their half-life is relatively short partly due to weak or absent binding to the neonatal Fc receptor (FcRn). We developed a novel approach to increase the eAd binding to FcRn based on a combination of structure-based design, computational modeling and phage display methodologies. By using this approach, we identified 2 IgG1 CH2-derived eAds fused to a short FcRn-binding motif derived from IgG1 CH3 that exhibited greatly ...[more]