Ontology highlight
ABSTRACT:
SUBMITTER: Mazor Y
PROVIDER: S-EPMC4622944 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Mazor Yariv Y Hansen Anna A Yang Chunning C Chowdhury Partha S PS Wang Jihong J Stephens Geoffrey G Wu Herren H Dall'Acqua William F WF
mAbs 20150101 3
Bispecific antibodies constitute a valuable class of therapeutics owing to their ability to bind 2 distinct targets. Dual targeting is thought to enhance biological efficacy, limit escape mechanisms, and increase target selectivity via a strong avidity effect mediated by concurrent binding to both antigens on the surface of the same cell. However, factors that regulate the extent of target selectivity are not well understood. We show that dual targeting alone is not sufficient to promote efficie ...[more]