Ontology highlight
ABSTRACT:
SUBMITTER: Bonvin P
PROVIDER: S-EPMC4623423 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bonvin Pauline P Venet Sophie S Fontaine Gaëlle G Ravn Ulla U Gueneau Franck F Kosco-Vilbois Marie M Proudfoot Amanda Ei AE Fischer Nicolas N
mAbs 20150101 2
pH-dependent antibodies are engineered to release their target at a slightly acidic pH, a property making them suitable for clinical as well as biotechnological applications. Such antibodies were previously obtained by histidine scanning of pre-existing antibodies, a labor-intensive strategy resulting in antibodies that displayed residual binding to their target at pH 6.0. We report here the de novo isolation of pH-dependent antibodies selected by phage display from libraries enriched in histidi ...[more]