Ontology highlight
ABSTRACT:
SUBMITTER: Hao L
PROVIDER: S-EPMC4623593 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
FEBS letters 20150417 12
Using rheumatoid arthritis (RA) and periodontitis mouse models, we demonstrate that RA and periodontitis share many pathological features, such as deregulated cytokine production, increased immune-cell infiltration, increased expression of Toll-like receptors (TLRs), and enhanced osteoclast activity and bone erosion. We reveal that genetic deletion of cathepsin K (Ctsk) caused a radical reduction in inflammation and bone erosion within RA joint capsules and periodontal lesions, a drastic decreas ...[more]