Insulin resistance in clinical and experimental alcoholic liver disease.
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ABSTRACT:
SUBMITTER: Carr RM
PROVIDER: S-EPMC4623941 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Insulin resistance in clinical and experimental alcoholic liver disease.
Carr Rotonya M RM Correnti Jason J
Annals of the New York Academy of Sciences 20150521
Alcoholic liver disease (ALD) is the number one cause of liver failure worldwide; its management costs billions of healthcare dollars annually. Since the advent of the obesity epidemic, insulin resistance (IR) and diabetes have become common clinical findings in patients with ALD; and the development of IR predicts the progression from simple steatosis to cirrhosis in ALD patients. Both clinical and experimental data implicate the impairment of several mediators of insulin signaling in ALD, and ...[more]
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