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Lipid A as a Drug Target and Therapeutic Molecule.

ABSTRACT: In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.

SUBMITTER: Joo SH

PROVIDER: S-EPMC4624066 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Lipid A as a Drug Target and Therapeutic Molecule.

Joo Sang Hoon SH

Biomolecules & therapeutics 20151101 6

In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lip ...[more]

PMID: 26535075

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