Unknown

Dataset Information

0

The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.


ABSTRACT: In metazoans, microRNAs play a critical role in the posttranscriptional regulation of genes required for cell proliferation and differentiation. MicroRNAs themselves are regulated by a multitude of mechanisms influencing their transcription and posttranscriptional maturation. However, there is only sparse knowledge on pathways regulating the mature, functional form of microRNA. Here, we uncover the implication of the decapping scavenger protein DCS-1 in the control of microRNA turnover. In Caenorhabditis elegans, mutations in dcs-1 increase the levels of functional microRNAs. We demonstrate that DCS-1 interacts with the exonuclease XRN-1 to promote microRNA degradation in an independent manner from its known decapping scavenger activity, establishing two molecular functions for DCS-1. Our findings thus indicate that DCS-1 is part of a degradation complex that performs microRNA turnover in animals.

SUBMITTER: Bosse GD 

PROVIDER: S-EPMC4624197 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.

Bossé Gabriel D GD   Rüegger Stefan S   Ow Maria C MC   Vasquez-Rifo Alejandro A   Rondeau Evelyne L EL   Ambros Victor R VR   Grosshans Helge H   Simard Martin J MJ  

Molecular cell 20130328 2


In metazoans, microRNAs play a critical role in the posttranscriptional regulation of genes required for cell proliferation and differentiation. MicroRNAs themselves are regulated by a multitude of mechanisms influencing their transcription and posttranscriptional maturation. However, there is only sparse knowledge on pathways regulating the mature, functional form of microRNA. Here, we uncover the implication of the decapping scavenger protein DCS-1 in the control of microRNA turnover. In Caeno  ...[more]

Similar Datasets

| S-EPMC4653633 | biostudies-literature
2016-05-23 | GSE69591 | GEO
| S-EPMC4544744 | biostudies-literature
| S-EPMC6565619 | biostudies-literature
| S-EPMC5147811 | biostudies-literature
| S-EPMC126188 | biostudies-literature
| S-EPMC4424953 | biostudies-literature
| S-EPMC5612656 | biostudies-literature
| S-EPMC5714490 | biostudies-literature
| S-EPMC2887956 | biostudies-literature