Ontology highlight
ABSTRACT:
SUBMITTER: Bosse GD
PROVIDER: S-EPMC4624197 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Bossé Gabriel D GD Rüegger Stefan S Ow Maria C MC Vasquez-Rifo Alejandro A Rondeau Evelyne L EL Ambros Victor R VR Grosshans Helge H Simard Martin J MJ
Molecular cell 20130328 2
In metazoans, microRNAs play a critical role in the posttranscriptional regulation of genes required for cell proliferation and differentiation. MicroRNAs themselves are regulated by a multitude of mechanisms influencing their transcription and posttranscriptional maturation. However, there is only sparse knowledge on pathways regulating the mature, functional form of microRNA. Here, we uncover the implication of the decapping scavenger protein DCS-1 in the control of microRNA turnover. In Caeno ...[more]