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T cells expressing CD123 chimeric antigen receptors for treatment of acute myeloid leukemia.

ABSTRACT: The purpose of this article is to discuss the rationale of targeting CD123 using chimeric antigen receptor (CAR) T cells for the treatment of leukemia.CD123 is a leukemia-associated antigen that expresses at high levels in leukemic stem cells and leukemic blasts and low level in normal hematopoietic stem/progenitor cells. Immune-based therapies targeting CD123 are being developed. Preclinical data suggest that CD123 CAR T cells exhibit potent antileukemic activity and various impacts on normal hematopoiesis.CD123 is an attractive surface target for novel antileukemic therapies. CD123 CAR T-cell-based immunotherapy is a promising treatment for patients with relapsed or refractory acute myeloid leukemia.

SUBMITTER: Mardiros A

PROVIDER: S-EPMC4624420 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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T cells expressing CD123 chimeric antigen receptors for treatment of acute myeloid leukemia.

Mardiros Armen A Forman Stephen J SJ Budde Lihua E LE

Current opinion in hematology 20151101 6

<h4>Purpose of review</h4>The purpose of this article is to discuss the rationale of targeting CD123 using chimeric antigen receptor (CAR) T cells for the treatment of leukemia.<h4>Recent findings</h4>CD123 is a leukemia-associated antigen that expresses at high levels in leukemic stem cells and leukemic blasts and low level in normal hematopoietic stem/progenitor cells. Immune-based therapies targeting CD123 are being developed. Preclinical data suggest that CD123 CAR T cells exhibit potent ant ...[more]

PMID: 26457961

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