Ontology highlight
ABSTRACT:
SUBMITTER: Pluta S
PROVIDER: S-EPMC4624464 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Pluta Scott S Naka Alexander A Veit Julia J Telian Gregory G Yao Lucille L Hakim Richard R Taylor David D Adesnik Hillel H
Nature neuroscience 20150928 11
Anatomical and physiological experiments have outlined a blueprint for the feedforward flow of activity in cortical circuits: signals are thought to propagate primarily from the middle cortical layer (layer 4, L4) up to L2/3 and down to the major cortical output layer (L5). Pharmacological manipulations, however, have contested this model and have suggested that L4 may not be critical for sensory responses of neurons in either superficial or deep layers. To address these conflicting models, we r ...[more]