Ontology highlight
ABSTRACT:
SUBMITTER: Yuan S
PROVIDER: S-EPMC4624681 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Yuan Shuai S Cao Lei L Ling Hui H Dang Minghao M Sun Yao Y Zhang Xuyuan X Chen Yutao Y Zhang Liguo L Su Dan D Wang Xiangxi X Rao Zihe Z
Protein & cell 20151101 11
Ebolavirus can cause hemorrhagic fever in humans with a mortality rate of 50%-90%. Currently, no approved vaccines and antiviral therapies are available. Human TIM1 is considered as an attachment factor for EBOV, enhancing viral infection through interaction with PS located on the viral envelope. However, reasons underlying the preferable usage of hTIM-1, but not other PS binding receptors by filovirus, remain unknown. We firstly demonstrated a direct interaction between hTIM-1 and EBOV GP in vi ...[more]