Ontology highlight
ABSTRACT:
SUBMITTER: Liu JL
PROVIDER: S-EPMC4624707 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20151027 10
<h4>Background</h4>Beclin 1 and Beclin 2 are autophagy-related proteins that show similar amino acid sequences and domain structures. Beclin 1 established the first connection between autophagy and cancer. However, the role of Beclin 2 in cancer is unclear. The aims of this study were to analyze Beclin 1 and Beclin 2 expressions in oral cancer tissues and in cell lines, and to evaluate their possible roles in cancer progression.<h4>Methods</h4>We investigated Beclin 1 and Beclin 2 expressions by ...[more]