Testing the reliability of hands and ears as biometrics: the importance of viewpoint.
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ABSTRACT:
SUBMITTER: Stevenage SV
PROVIDER: S-EPMC4624835 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:The problem of statistically evaluating forecasting systems is revisited. The forecaster claims the forecasts to exhibit a certain nominal statistical behaviour; for instance, the forecasts provide the expected value (or certain quantiles) of the verification, conditional on the information available at forecast time. Forecasting systems that indeed exhibit the nominal behaviour are referred to as reliable. Statistical tests for reliability are presented (based on an archive of verification–forecast pairs). As noted previously, devising such tests is encumbered by the fact that the dependence structure of the verification–forecast pairs is not known in general. Ignoring this dependence though might lead to incorrect tests and too-frequent rejection of forecasting systems that are actually reliable. On the other hand, reliability typically implies that the forecast provides information about the dependence structure, and using this in conjunction with judicious choices of the test statistic, rigorous results on the asymptotic distribution of the test statistic are obtained. These results are used to test for reliability under minimal additional assumptions on the statistical properties of the verification–forecast pairs. Applications to environmental forecasts are discussed. A python implementation of the discussed methods is available online.
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2021-04-21 | GSE172404 | GEO
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Project description:AimsGenetic testing is recommended in specific inherited heart diseases but its role remains unclear and it is not currently recommended in unexplained cardiac arrest (UCA). We sought to assess the yield and clinical utility of genetic testing in UCA using whole-exome sequencing (WES).Methods and resultsSurvivors of UCA requiring external defibrillation were included from the Cardiac Arrest Survivor with Preserved Ejection fraction Registry. Whole-exome sequencing was performed, followed by assessment of rare variants in previously reported cardiovascular disease genes. A total of 228 UCA survivors (mean age at arrest 39 ± 13 years) were included. The majority were males (66%) and of European ancestry (81%). Following advanced clinical testing at baseline, the likely aetiology of cardiac arrest was determined in 21/228 (9%) cases. Whole-exome sequencing identified a pathogenic or likely pathogenic (P/LP) variant in 23/228 (10%) of UCA survivors overall, increasing the proportion of 'explained' cases from 9% only following phenotyping to 18% when combining phenotyping with WES. Notably, 13 (57%) of the 23 P/LP variants identified were located in genes associated with cardiomyopathy, in the absence of a diagnosis of cardiomyopathy at the time of arrest.ConclusionsGenetic testing identifies a disease-causing variant in 10% of apparent UCA survivors. The majority of disease-causing variants was located in cardiomyopathy-associated genes, highlighting the arrhythmogenic potential of such variants in the absence of an overt cardiomyopathy diagnosis. The present study supports the use of genetic testing including assessment of arrhythmia and cardiomyopathy genes in survivors of UCA.
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Project description:ObjectiveTo evaluate learning results of critical care physiotherapists participating in a muscle ultrasound (MUS) educational program.DesignCross-sectional study.SettingA custom-made 20-hour MUS course was performed over a 2-week time period, including knobs familiarization, patient positioning, anatomic landmarks, image acquisition, and limb muscle measurements.ParticipantsNineteen critical care physiotherapists with little to no prior experience in ultrasound (N=19).InterventionsNot applicable.Main outcome measuresTheoretical knowledge, hands-on skills acquisition, and satisfaction were assessed. Inter- and intrarater reliability on landmarks, thickness, and pennation angle of quadriceps between participants was evaluated using intraclass correlation coefficients (ICCs). Reliability among instructors measured prior to the course was also reported as a reference.ResultsThe percentage score (mean±SD) of knowledge questionnaires was 69±11 (pre-course), 89±10 (post-course), and 92±9 (hands-on skills). Course satisfaction scores ranged from 90%-100%. Pooled interrater reliability of participants (median ICC [interquartile range]) was good (0.70 [0.59-0.79]) for thickness, moderate (0.47 [0.46-0.92]) for landmarks, and absent (0.00 [0.00-0.05]) for pennation angle and the intrarater reliability was good (0.76 [0.51-0.91]) for thickness and weak (0.35 [0.29-0.52]) for pennation angle. Interrater ICC values for instructors were excellent (0.90) for thickness, good (0.67) for landmarks, and moderate (0.41) for pennation angle and intrarater ICC values were excellent (0.94) for thickness and good (0.75) for pennation angle.ConclusionsAlthough our sample was quite small and homogeneous, increased theoretical knowledge, high hands-on performance acquisition, and good satisfaction of physiotherapists were observed. Reliability was moderate to excellent for thickness and landmarks and absent to weak for pennation angle. Landmarking and pennation angle remain challenges for physiotherapist training in the application of MUS. Further studies are needed to identify variables that could modify reliability during MUS training.
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