Ontology highlight
ABSTRACT:
SUBMITTER: Fiorucci S
PROVIDER: S-EPMC4624933 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Fiorucci Sandrine S Lin Xiaochen X Sadoul Karin K Fournet Guy G Bouvard Daniel D Vinogradova Olga O Joseph Benoît B Block Marc R MR
PloS one 20151028 10
We previously reported the anti-migratory function of 3-aryl-2-quinolone derivatives, chemically close to flavonoids (Joseph et al., 2002). Herein we show that 3-arylquinoline or 3-aryl-2-quinolone derivatives disrupt cell adhesion in a dose dependent and reversible manner yet antagonized by artificial integrin activation such as manganese. Relying on this anti-adhesive activity, a Structure-Activity Relationship (SAR) study was established on 20 different compounds to throw the bases of future ...[more]