Cerebral Cortex Expression of Gli3 Is Required for Normal Development of the Lateral Olfactory Tract.

ABSTRACT: Formation of the lateral olfactory tract (LOT) and innervation of the piriform cortex represent fundamental steps to allow the transmission of olfactory information to the cerebral cortex. Several transcription factors, including the zinc finger transcription factor Gli3, influence LOT formation by controlling the development of mitral cells from which LOT axons emanate and/or by specifying the environment through which these axons navigate. Gli3 null and hypomorphic mutants display severe defects throughout the territory covered by the developing lateral olfactory tract, making it difficult to identify specific roles for Gli3 in its development. Here, we used Emx1Cre;Gli3fl/fl conditional mutants to investigate LOT formation and colonization of the olfactory cortex in embryos in which los

SUBMITTER: Amaniti EM 

PROVIDER: S-EPMC4624982 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature