Dataset Information

Contrast-dependent orientation discrimination in the mouse.

ABSTRACT: As an important animal model to study the relationship between behaviour and neural activity, the mouse is able to perform a variety of visual tasks, such as orientation discrimination and contrast detection. However, it is not clear how stimulus contrast influences the performance of orientation discrimination in mice. In this study, we used two task designs, two-alternative forced choice (2AFC) and go/no-go, to examine the performance of mice to discriminate two orthogonal orientations at different contrasts. We found that the performance tended to increase with contrast, and the performance at high contrast was better when the stimulus set contained a single contrast than multiple contrasts. Physiological experiments in V1 showed that neural discriminability of two orthogonal orientations increased with contrast. Furthermore, orientation discriminability of V1 neurons at high contrast was higher in the single than in the multiple contrast condition, largely due to smaller response variance in the single contrast condition. Thus, the performance of mice to discriminate orientations at high contrast is adapted to the contrast range in the stimuli, partly attributed to the contrast-range dependent capacity of V1 neurons to discriminate orientations.

SUBMITTER: Long M

PROVIDER: S-EPMC4625186 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Contrast-dependent orientation discrimination in the mouse.

Long Minghai M Jiang Weiqian W Liu Dechen D Yao Haishan H

Scientific reports 20151029

As an important animal model to study the relationship between behaviour and neural activity, the mouse is able to perform a variety of visual tasks, such as orientation discrimination and contrast detection. However, it is not clear how stimulus contrast influences the performance of orientation discrimination in mice. In this study, we used two task designs, two-alternative forced choice (2AFC) and go/no-go, to examine the performance of mice to discriminate two orthogonal orientations at diff ...[more]

PMID: 26510881

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Project description:Purpose: We present a phase-contrast x-ray tomography study of wild type C57BL/6 mouse hearts as a nondestructive approach to the microanatomy on the scale of the entire excised organ. Based on the partial coherence at a home-built phase-contrast ?-CT setup installed at a liquid metal jet source, we exploit phase retrieval and hence achieve superior image quality for heart tissue, almost comparable to previous synchrotron data on the whole organ scale. Approach: In our work, different embedding methods and heavy metal-based stains have been explored. From the tomographic reconstructions, quantitative structural parameters describing the three-dimensional (3-D) architecture have been derived by two different fiber tracking algorithms. The first algorithm is based on the local gradient of the reconstructed electron density. By performing a principal component analysis on the local structure-tensor of small subvolumes, the dominant direction inside the volume can be determined. In addition to this approach, which is already well established for heart tissue, we have implemented and tested an algorithm that is based on a local 3-D Fourier transform. Results: We showed that the choice of sample preparation influences the 3-D structure of the tissue, not only in terms of contrast but also with respect to the structural preservation. A heart prepared with the evaporation-of-solvent method was used to compare both algorithms. The results of structural orientation were very similar for both approaches. In addition to the determination of the fiber orientation, the degree of filament alignment and local thickness of single muscle fiber bundles were obtained using the Fourier-based approach. Conclusions: Phase-contrast x-ray tomography allows for investigating the structure of heart tissue with an isotropic resolution below 10???m . The fact that this is possible with compact laboratory instrumentation opens up new opportunities for screening samples and optimizing sample preparation, also prior to synchrotron beamtimes. Further, results from the structural analysis can help in understanding cardiovascular diseases or can be used to improve computational models of the heart.

Project description:Cognition is very important in our daily life. However, amblyopia has abnormal visual cognition. Physiological changes of the brain during processes of cognition could be reflected with ERPs. So the purpose of this study was to investigate the speed and the capacity of resource allocation in visual cognitive processing in orientation discrimination task during monocular and binocular viewing conditions of amblyopia and normal control as well as the corresponding eyes of the two groups with ERPs. We also sought to investigate whether the speed and the capacity of resource allocation in visual cognitive processing vary with target stimuli at different spatial frequencies (3, 6 and 9 cpd) in amblyopia and normal control as well as between the corresponding eyes of the two groups. Fifteen mild to moderate anisometropic amblyopes and ten normal controls were recruited. Three-stimulus oddball paradigms of three different spatial frequency orientation discrimination tasks were used in monocular and binocular conditions in amblyopes and normal controls to elicit event-related potentials (ERPs). Accuracy (ACC), reaction time (RT), the latency of novelty P300 and P3b, and the amplitude of novelty P300 and P3b were measured. Results showed that RT was longer in the amblyopic eye than in both eyes of amblyopia and non-dominant eye in control. Novelty P300 amplitude was largest in the amblyopic eye, followed by the fellow eye, and smallest in both eyes of amblyopia. Novelty P300 amplitude was larger in the amblyopic eye than non-dominant eye and was larger in fellow eye than dominant eye. P3b latency was longer in the amblyopic eye than in the fellow eye, both eyes of amblyopia and non-dominant eye of control. P3b latency was not associated with RT in amblyopia. Neural responses of the amblyopic eye are abnormal at the middle and late stages of cognitive processing, indicating that the amblyopic eye needs to spend more time or integrate more resources to process the same visual task. Fellow eye and both eyes in amblyopia are slightly different from the dominant eye and both eyes in normal control at the middle and late stages of cognitive processing. Meanwhile, abnormal extents of amblyopic eye do not vary with three different spatial frequencies used in our study.

Dataset Information

Contrast-dependent orientation discrimination in the mouse.

Publications

Contrast-dependent orientation discrimination in the mouse.

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