A positive-negative mode of population covariation links brain connectivity, demographics and behavior.
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ABSTRACT:
SUBMITTER: Smith SM
PROVIDER: S-EPMC4625579 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
A positive-negative mode of population covariation links brain connectivity, demographics and behavior.
Smith Stephen M SM Nichols Thomas E TE Vidaurre Diego D Winkler Anderson M AM Behrens Timothy E J TE Glasser Matthew F MF Ugurbil Kamil K Barch Deanna M DM Van Essen David C DC Miller Karla L KL
Nature neuroscience 20150928 11
We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain c ...[more]
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