Ontology highlight
ABSTRACT:
SUBMITTER: van der Valk FM
PROVIDER: S-EPMC4625798 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
van der Valk Fleur M FM van Wijk Diederik F DF Lobatto Mark E ME Verberne Hein J HJ Storm Gert G Willems Martine C M MC Legemate Dink A DA Nederveen Aart J AJ Calcagno Claudia C Mani Venkatesh V Ramachandran Sarayu S Paridaans Maarten P M MP Otten Maarten J MJ Dallinga-Thie Geesje M GM Fayad Zahi A ZA Nieuwdorp Max M Schulte Dominik M DM Metselaar Josbert M JM Mulder Willem J M WJ Stroes Erik S ES
Nanomedicine : nanotechnology, biology, and medicine 20150317 5
Drug delivery to atherosclerotic plaques via liposomal nanoparticles may improve therapeutic agents' risk-benefit ratios. Our paper details the first clinical studies of a liposomal nanoparticle encapsulating prednisolone (LN-PLP) in atherosclerosis. First, PLP's liposomal encapsulation improved its pharmacokinetic profile in humans (n=13) as attested by an increased plasma half-life of 63h (LN-PLP 1.5mg/kg). Second, intravenously infused LN-PLP appeared in 75% of the macrophages isolated from i ...[more]