Ontology highlight
ABSTRACT:
SUBMITTER: Aceto GM
PROVIDER: S-EPMC4625907 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Aceto Gitana Maria GM Fantini Fabiana F De Iure Sabrina S Di Nicola Marta M Palka Giandomenico G Valanzano Rosa R Di Gregorio Patrizia P Stigliano Vittoria V Genuardi Maurizio M Battista Pasquale P Cama Alessandro A Curia Maria Cristina MC
Journal of experimental & clinical cancer research : CR 20151028
<h4>Background</h4>Transcript dosage imbalance may influence the transcriptome. To gain insight into the role of altered gene expression in hereditary colorectal polyposis predisposition, in the present study we analyzed absolute and allele-specific expression (ASE) of adenomatous polyposis coli (APC) and mutY Homolog (MUTYH) genes.<h4>Methods</h4>We analyzed DNA and RNA extracted from peripheral blood mononuclear cells (PBMC) of 49 familial polyposis patients and 42 healthy blood donors selecte ...[more]