Ontology highlight
ABSTRACT:
SUBMITTER: Grega-Larson NE
PROVIDER: S-EPMC4626065 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Grega-Larson Nathan E NE Crawley Scott W SW Erwin Amanda L AL Tyska Matthew J MJ
Molecular biology of the cell 20150909 21
Microvilli are actin-based protrusions found on the surface of diverse cell types, where they amplify membrane area and mediate interactions with the external environment. In the intestinal tract, these protrusions play central roles in nutrient absorption and host defense and are therefore essential for maintaining homeostasis. However, the mechanisms controlling microvillar assembly remain poorly understood. Here we report that the multifunctional actin regulator cordon bleu (COBL) promotes th ...[more]