WASP: allele-specific software for robust molecular quantitative trait locus discovery.
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ABSTRACT:
SUBMITTER: van de Geijn B
PROVIDER: S-EPMC4626402 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
WASP: allele-specific software for robust molecular quantitative trait locus discovery.
van de Geijn Bryce B McVicker Graham G Gilad Yoav Y Pritchard Jonathan K JK
Nature methods 20150914 11
Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical artifacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and chromatin immunoprecipitation sequencing (ChIP-seq) reads, we demonstrate that WASP has a low error rate and is far more powerful than existing QTL-mappi ...[more]
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