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Bioactive Mimetics of Conotoxins and other Venom Peptides.

ABSTRACT: Ziconotide (Prialt®), a synthetic version of the peptide ?-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode of delivery and narrow therapeutic window cause complications for patients. This review will summarize progress in the development of small molecule, non-peptidic mimics of Conotoxins and a small number of other venom peptides. This will include a description of how some of the initially designed mimics have been modified to improve their drug-like properties.

SUBMITTER: Duggan PJ

PROVIDER: S-EPMC4626728 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Bioactive Mimetics of Conotoxins and other Venom Peptides.

Duggan Peter J PJ Tuck Kellie L KL

Toxins 20151016 10

Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode of delivery and narrow therapeutic window cause complications for patients. This review will summarize progress in the development of small molecule, non-peptidic mimics of Conotoxins and a small number of other venom peptides. This will include ...[more]

PMID: 26501323

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