Ontology highlight
ABSTRACT:
SUBMITTER: Pesapane A
PROVIDER: S-EPMC4627239 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Pesapane Ada A Di Giovanni Carmen C Rossi Francesca Wanda FW Alfano Daniela D Formisano Luigi L Ragno Pia P Selleri Carmine C Montuori Nunzia N Lavecchia Antonio A
Oncotarget 20150701 20
The 67 kDa laminin receptor (67LR) is a non-integrin receptor for laminin (LM) that derives from a 37 kDa precursor (37LRP). 67LR expression is increased in neoplastic cells and correlates with an enhanced invasive and metastatic potential. We used structure-based virtual screening (SB-VS) to search for 67LR inhibitory small molecules, by focusing on a 37LRP sequence, the peptide G, able to specifically bind LM. Forty-six compounds were identified and tested on HEK-293 cells transfected with 37L ...[more]