Ontology highlight
ABSTRACT:
SUBMITTER: Suleiman AA
PROVIDER: S-EPMC4627460 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Suleiman Ahmed Abbas AA Frechen Sebastian S Scheffler Matthias M Zander Thomas T Nogova Lucia L Kocher Martin M Jaehde Ulrich U Wolf Jürgen J Fuhr Uwe U
The AAPS journal 20150819 6
Treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor used for treating non-small-cell lung cancer (NSCLC) and other cancers, is frequently associated with adverse events (AE). We present a modeling and simulation framework for the most common erlotinib-induced AE, rash, and diarrhea, providing insights into erlotinib toxicity. We used the framework to investigate the safety of high-dose erlotinib pulses proposed to limit acquired resistance while treating NSCLC ...[more]