Ontology highlight
ABSTRACT:
SUBMITTER: Slattery CF
PROVIDER: S-EPMC4627504 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Slattery Catherine F CF Beck Jonathan A JA Harper Lorna L Adamson Gary G Abdi Zeinab Z Uphill James J Campbell Tracy T Druyeh Ron R Mahoney Colin J CJ Rohrer Jonathan D JD Kenny Janna J Lowe Jessica J Leung Kelvin K KK Barnes Josephine J Clegg Shona L SL Blair Melanie M Nicholas Jennifer M JM Guerreiro Rita J RJ Rowe James B JB Ponto Claudia C Zerr Inga I Kretzschmar Hans H Gambetti Pierluigi P Crutch Sebastian J SJ Warren Jason D JD Rossor Martin N MN Fox Nick C NC Collinge John J Schott Jonathan M JM Mead Simon S
Alzheimer's & dementia : the journal of the Alzheimer's Association 20140823 6
<h4>Background</h4>Rare TREM2 variants are significant risk factors for Alzheimer's disease (AD).<h4>Methods</h4>We used next generation sequencing of the whole gene (n = 700), exon 2 Sanger sequencing (n = 2634), p.R47H genotyping (n = 3518), and genome wide association study imputation (n = 13,048) to determine whether TREM2 variants are risk factors or phenotypic modifiers in patients with AD (n = 1002), frontotemporal dementia (n = 358), sporadic (n = 2500), and variant (n = 115) Creutzfeldt ...[more]