Ontology highlight
ABSTRACT:
SUBMITTER: Brideau NJ
PROVIDER: S-EPMC4628070 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Brideau Nicholas J NJ Coker Heather H Gendrel Anne-Valerie AV Siebert C Alistair CA Bezstarosti Karel K Demmers Jeroen J Poot Raymond A RA Nesterova Tatyana B TB Brockdorff Neil N
Molecular and cellular biology 20150921 23
The chromosomal protein SMCHD1 plays an important role in epigenetic silencing at diverse loci, including the inactive X chromosome, imprinted genes, and the facioscapulohumeral muscular dystrophy locus. Although homology with canonical SMC family proteins suggests a role in chromosome organization, the mechanisms underlying SMCHD1 function and target site selection remain poorly understood. Here we show that SMCHD1 forms an active GHKL-ATPase homodimer, contrasting with canonical SMC complexes, ...[more]