Ontology highlight
ABSTRACT:
SUBMITTER: Shugrue CR
PROVIDER: S-EPMC4628550 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Shugrue Christopher R CR Miller Scott J SJ
Angewandte Chemie (International ed. in English) 20150805 38
Phosphothreonine (pThr) was found to constitute a new class of chiral phosphoric acid (CPA) catalyst upon insertion into peptides. To demonstrate the potential of these phosphopeptides as asymmetric catalysts, enantioselective transfer hydrogenations of a previously underexplored substrate class for CPA-catalyzed reductions were carried out. pThr-containing peptides lead to the observation of enantioselectivities of up to 94:6 e.r. with 2-substituted quinolines containing C8-amino functionality. ...[more]