Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice.
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ABSTRACT:
SUBMITTER: Noda K
PROVIDER: S-EPMC4628642 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice.
Noda Kazuo K Nakamura Tomoyuki T Komatsu Yoshihiro Y
Biochemical and biophysical research communications 20150921 3
Craniofacial sutures govern the shape of the craniofacial skeleton during postnatal development. The differentiation of suture mesenchymal cells to osteoblasts is precisely regulated in part by signaling through cell surface receptors that interact with extracellular proteins. Here we report that fibulin-5, a key extracellular matrix protein, is important for craniofacial skeletal development in mice. Fibulin-5 is deposited as a fibrous matrix in cranial neural crest-derived mesenchymal tissues, ...[more]
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