Ontology highlight
ABSTRACT:
SUBMITTER: Karantalis V
PROVIDER: S-EPMC4628729 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Karantalis Vasileios V Suncion-Loescher Viky Y VY Bagno Luiza L Golpanian Samuel S Wolf Ariel A Sanina Cristina C Premer Courtney C Kanelidis Anthony J AJ McCall Frederic F Wang Bo B Balkan Wayne W Rodriguez Jose J Rosado Marcos M Morales Azorides A Hatzistergos Konstantinos K Natsumeda Makoto M Margitich Irene I Schulman Ivonne Hernandez IH Gomes Samirah A SA Mushtaq Muzammil M DiFede Darcy L DL Fishman Joel E JE Pattany Pradip P Zambrano Juan Pablo JP Heldman Alan W AW Hare Joshua M JM
Journal of the American College of Cardiology 20151101 18
<h4>Background</h4>Both bone marrow-derived mesenchymal stem cells (MSCs) and c-kit(+) cardiac stem cells (CSCs) improve left ventricular remodeling in porcine models and clinical trials. Using xenogeneic (human) cells in immunosuppressed animals with acute ischemic heart disease, we previously showed that these 2 cell types act synergistically.<h4>Objectives</h4>To more accurately model clinical applications for heart failure, this study tested whether the combination of autologous MSCs and CSC ...[more]