Ontology highlight
ABSTRACT:
SUBMITTER: Lo DJ
PROVIDER: S-EPMC4628789 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Lo D J DJ Anderson D J DJ Song M M Leopardi F F Farris A B AB Strobert E E Chapin S S Devens B B Karrer E E Kirk A D AD
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20150220 4
Costimulation blockade with the B7-CD28 pathway-specific agent belatacept is now used in clinical kidney transplantation, but its efficacy remains imperfect. Numerous alternate costimulatory pathways have been proposed as targets to synergize with belatacept, one of which being the inducible costimulator (ICOS)-ICOS ligand (ICOS-L) pathway. Combined ICOS-ICOS-L and CD28-B7 blockade has been shown to prevent rejection in mice, but has not been studied in primates. We therefore tested a novel ICOS ...[more]