Ontology highlight
ABSTRACT:
SUBMITTER: Ponnala S
PROVIDER: S-EPMC4628873 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Ponnala Shashikanth S Kapadia Nirav N Madapa Sudharshan S Alberts Ian L IL Harding Wayne W WW
Bioorganic & medicinal chemistry letters 20151009 22
A series of C1 aporphine analogs related to compound 5 and that contain substituted allylic, alkynyl, nitrile, ester and benzyl groups was synthesized and evaluated for affinity at h5HT2A and α1A receptors in functional activity assays that measure calcium release. The presence of branched allylic substituent groups diminished affinity for the h5HT2A receptor. Likewise, the alkynyl, nitrile and ester derivatives evaluated displayed lower 5-HT2A receptor affinity as compared to 5. Hydrophobic, st ...[more]